Auvelity is an oral psychiatric drug initially approved by the FDA in August 2022 for adults with Major Depressive Disorder (MDD). It claims to show symptom improvement in as quickly as one week – “statistically significant antidepressant efficacy starting at one week when compared to a placebo.”
There are 17 “Major depressive disorder” diagnoses in the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders revision 5), so it is relatively easy to diagnose someone with MDD. This is also known as “clinical depression”, which is curious because there are no clinical tests for it; no blood test, no urine test, no biopsy, no MRI, no ultrasound, no x-ray, no CT scan, no genetic test, etc.
Treatment typically involves psychotherapy and/or antidepressant drugs.
Auvelity is an extended-release combination of dextromethorphan (e.g. brand name Robitussin cough suppressant) and bupropion (e.g. brand name Wellbutrin). Like all other antidepressants, it can have side effects of suicide and violence, as well as just worsening one’s depression. Seizures, delusions and hallucinations are also serious possible side effects. The list of possible adverse reactions is quite long, and are listed in the manufacturer’s prescribing instructions.
It is not known if Auvelity is safe and effective in children. It carries a boxed warning for increased suicidal thoughts in young adults, although it has been known since at least 2007 that antidepressants increase the risk of violence, homicide and suicide at any age.
They don’t really know how it is supposed to work. “The mechanism of dextromethorphan in the treatment of MDD … is unclear.” and “The mechanism of action of bupropion in the treatment of MDD is unclear.” [quotes from the manufacturer’s prescribing information.]
Naturally they want more funds to continue testing it for more uses — “More studies investigating the efficacy and efficiency of Auvelity in patients with MDD and other related neurological disorders and comorbidities are required to give a better insight.”
Why use a cough suppressant for depression?
Dextromethorphan acts as a glutamate (neurotransmitter) blocker (similar to ketamine, a dissociative anesthetic) and a serotonin booster. We already know the whole fraudulent serotonin theory of depression has been thoroughly debunked.
Technically, the bupropion prevents the enzyme cytochrome P450 2D6 (CYP2D6) from quickly metabolizing the dextromethorphan. [See “More About Psychiatric Drugs Causing Violence and Suicide” for more information about cytochrome P450 and psychiatric drugs, and how this relates to the side effects of violence and suicide.]
They’ve tried mixing bupropion with another drug before (brand name Contrave). You’d think they might have learned something from that. But apparently all they learned was that they can continue selling the same harmful psychiatric drug under new names to extend its income potential with new diagnoses and new patients.
People can, of course, experience symptoms commonly labeled as depression. In fact, there are hundreds of genuine medical conditions which can produce such mental symptoms — each of which has clinical tests and recognized medical treatments which do not involve psychiatric drugs.
These drugs mask the real cause of problems in life and debilitate the individual, so denying him or her the opportunity for real recovery and hope for the future. This is the real reason why psychiatry is a violation of human rights. Psychiatric treatment is not just a failure — it is routinely destructive to the individual and one’s mental health.
If you know someone who has bought into these lies, suggest they investigate non-psychiatric, non-drug alternatives. Contact your local, state and federal representatives and demand that they stop government funding of these drugs.
If you are taking this drug, do not stop suddenly. You could suffer serious withdrawal symptoms. You should seek the advice and help of a competent medical doctor or practitioner before trying to come off any psychiatric drug.

