More About Psychiatric Drugs Causing Violence and Suicide

Reference:

Antidepressant-induced akathisia-related homicides associated with diminishing mutations in metabolizing genes of the CYP450 family
by Yolande Lucire and Christopher Crotty
Pharmacogenomics and Personalized Medicine, 1 August 2011
[doi: 10.2147/PGPM.S17445]

This research paper details patients who had been referred to Dr. Lucire’s practice for expert opinion or treatment. More than 120 subjects were diagnosed with akathisia [a neurotoxic psychosis often characterized by a feeling of inner restlessness and inability to stay still] or serotonin toxicity [extremely high levels of serotonin causing toxic and potentially fatal effects] after taking psychiatric drugs that had been prescribed for psychosocial distress. Akathisia has been known to be associated with suicide since the 1950s and with homicide since 1985.

They were tested for variant alleles in cytochrome P450 (CYP450) genes, which play a major role in the metabolism of all antidepressant and many other drugs, indicating ultrarapid metabolism due to allele duplications. This seems to be strongly associated with a large number of deaths from intoxication and suicide. High or fast-changing levels of psychotropic substances can cause unpredictable toxicity leading to violent behavioral effects, including akathisia. [An allele is one of two or more alternative forms of a gene that arise by mutation and are found at the same place on a chromosome.]

Psychiatric drugs are metabolized in the liver by cytochrome P450 enzymes in order to be eliminated from the body. Abnormal CYP450 metabolism, either ultrarapid and/or diminished, can lead to the drug or its metabolites reaching a toxic level in hours or days, correlating with the onset of intense dysphoria [unease or generalized dissatisfaction with life] and akathisia. A person genetically deficient in these enzymes, or who has an ultrarapid drug metabolism, or who is taking other (legal or illegal) drugs that diminish CYP450 enzyme activity, is at risk of a toxic accumulation of the drug leading to more severe side effects.

Eight of these cases had committed homicide and many more became extremely violent or suicidal while on antidepressants. Ten representative case histories involving serious violence are presented in great detail in the paper. None of the ten subjects described had any history of mental illness; none had been violent before. All recovered from akathisia after stopping the medication without assistance or supervision and, frequently, against medical advice.

Akathisia suicides and homicides, particularly when they involved children, gave rise to the first antidepressant suicide advisories by the FDA in 2004.

Personal, medical, and legal problems can arise from using psychiatric drugs and experiencing the resulting toxicity from these metabolic effects. The results presented in this paper demonstrate the grave extent to which the psychiatric industry has expanded its influence beyond its ability to cure.

As the authors state, “In all of the cases presented here, the subjects were prescribed antidepressants that failed to mitigate distress emerging from their predicaments, which encompassed psychosocial stressors such as bereavement, marital and relationship difficulties, and work-related stress. Every subject’s emotional reaction worsened while their prescribing physicians continued the “trial and error” approach, increasing from standard to higher dose and/or switching to other antidepressants, with disastrous consequences. In some cases the violence ensued from changes occasioned by withdrawal and polypharmacy. In all of these cases, the subjects were put into a state of drug-induced toxicity manifesting as akathisia, which resolved only upon discontinuation of the antidepressant drugs.”

“It is the authors’ contention that prescribing antidepressants without knowing about CYP450 genotypes is like giving blood transfusions without matching for ABO groups [the classification of human blood].”

In general, the psychiatric industry pushes psychotropic drugs without regard to these CYP450 cautions, but this is the direct result of the unscientific psychiatric diagnoses perpetrated by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) which fraudulently justifies prescribing these harmful drugs for profit in the first place.

Recommendations

1. Practice Full Informed Consent by asking your doctor for information about possible side effects and benefits, ways to treat side effects, and risks of other conditions, as well as information about alternative treatments.

2. If your doctor diagnoses a mental disorder and prescribes a psychiatric drug, ask to see the clinical lab tests proving the diagnosis. (There won’t be any.)

3. All treatment options should include checking for real underlying medical conditions that could cause a patient’s mental or emotional duress.

4. Write your state and federal legislators to establish rights for patients and their insurance companies to receive refunds for mental health treatment which did not achieve the promised result or improvement, or which resulted in proven harm to the individual, thereby ensuring that responsibility lies with the individual practitioner and psychiatric facility rather than the government or its agencies.

5. The Diagnostic and Statistical Manual of Mental Disorders (DSM-5), psychiatry’s billing manual for mental disorders, is the key to false escalating mental illness statistics and psychiatric drug prescriptions and usage worldwide. Untold harm and colossal waste of mental health funds occur because of it. It is imperative that the DSM diagnostic system be abandoned before real mental health reform can occur.

6. Patients, doctors and insurance companies should report all instances of adverse side effects from psychiatric drugs to the FDA.

7. The pernicious influence of psychiatry has wreaked havoc throughout society, especially in hospitals, educational systems and prisons. Citizens groups and responsible government officials should work together to expose and abolish psychiatry’s hidden manipulation of society for profit.

They say TD is Manageable; They Lie

A recent spate of TV ads points to a new public relations campaign by the psychopharmaceutical mental health industry masquerading as a public service in an attempt to downplay the disastrous side effects of psychiatric drugs.

The tag line is “TD is Manageable“; TD being Tardive Dyskinesia [tardive, “late appearing” and dyskinesia, “abnormal muscle movement”], in which the muscles of the face and body contort and spasm involuntarily.

It has been known for a long time that the use of antipsychotics and other psychiatric drugs, prescribed for so-called schizophrenia and other fraudulent psychiatric diagnoses, may lead to tardive dyskinesia which causes random muscle movements that a person can’t control, and in some cases are permanent and cannot be cured.

Some research has also shown that TD may precipitate cognitive impairment.

On Feb. 11, 2014, a Chicago jury awarded $1.5 million to an autistic child who developed a severe case of irreversible tardive dyskinesia while being treated by psychiatrists with Risperdal and then Zyprexa between 2002 and 2007.

Since there is no known cure for TD, this public relations campaign is designed to make people feel that it isn’t so bad after all when the body jerks around for no reason. The best they can suggest is to talk to your doctor about it, reduce stress, and oh! by the way! you can also take this new psychiatric drug Ingrezza (generic valbenazine).

So, we finally see that this PR campaign is not really a public service, it’s about selling more psychiatric drugs.

Ingrezza from Neurocrine Biosciences, Inc. is believed to reduce dopamine release in the brain (they don’t really know how it “works”.)

The body must strictly regulate dopamine levels since both an excess and a deficiency can be problematic. Drugs which mess with dopamine play Russian roulette with your brain. And of course this drug has the usual range of adverse reactions, including akathisia (a movement disorder that makes it hard to stay still) which is just another form of TD.

The only real way to “manage” TD is not to get it in the first place by not taking any psychiatric drugs. Recognize that the real problem is that psychiatrists fraudulently diagnose life’s problems as an “illness”, and stigmatize unwanted behavior as “diseases,” so that they can make a buck selling drugs whose side effects make you a patient for life. Psychiatry’s stigmatizing labels, programs and treatments are harmful junk science; their diagnoses of “mental disorders” are a hoax — unscientific, fraudulent and harmful.

Cratered by Kratom

Kratom is an increasingly popular drug of abuse and readily available on the “recreational” drug market. Between 3 million and 5 million people in the U.S. use kratom, and reported poisonings from people taking it have soared.

The U.S. Food and Drug Administration (FDA) has warned against using Mitragyna Speciosa, commonly known as kratom, a tree in the coffee family which grows naturally in Thailand, Malaysia, Indonesia, Philippines, Vietnam, Myanmar, and Papua New Guinea. The concern is that kratom leaves, which affect the same opioid brain receptors as morphine, appear to have properties that expose users to the risks of addiction, abuse, and dependence.

There are no FDA-approved uses for kratom because there is no scientific evidence to support its medical use, and the FDA urges consumers to report any adverse reactions to the FDA’s MedWatch program.

The race is on to get patents for synthetics and derivatives of Mitragyna Speciosa. Doctors and mental health workers need to be aware of the psychopathological effects of these substances.

Because kratom is still legal in the U.S., it has become a go-to drug for individuals with chronic pain, promoted anecdotally by some psychiatrists both to mitigate pain and to ease withdrawal from other opioids.

Some other psychiatrists are convinced of kratom’s mental health benefits as a potential therapeutic agent.

Here again we see psychiatry, with its long history of harmful drug pushing, justifying and promoting the latest in a long line of such harmful, addictive and psychedelic drugs.

Similar to the dose-dependent characteristics of any drug, in relatively small amounts kratom acts as a stimulant; in relatively larger amounts it causes sedation; and when overdosed it can cause death.

Kratom’s psychoactive compounds, mitragynine and 7-hydroxymitragynine, are opioid-receptor agonists, which means they are chemicals that bind to the same receptors in the brain to which opioids bind, thus acting in the brain similar to other opioids like morphine and codeine.

Side effects of taking (or withdrawing from) kratom may include dependence, nausea, vomiting, aggression, hallucinations, delusions, psychosis, seizures, thyroid problems, increased risk of suicide, trouble breathing, brain swelling, seizures, liver damage, or death.

In spite of the American Kratom Association’s lobbying efforts to promote this harmful substance, and its repeated references to the American Psychiatric Association for support, we find that there is sufficient reason to be highly skeptical.

Click here for more information about kratom.

Psychiatric Inpatients Have Elevated Risks for Adverse Reactions

[Reference: “Multiple adverse outcomes following first discharge from inpatient psychiatric care: a national cohort study”, The Lancet Psychiatry, June 03, 2019]

People discharged from inpatient psychiatric care are at higher risk than the rest of the population for a range of serious fatal and non-fatal adverse outcomes.

These individuals are also more likely to perpetrate violent crimes, including homicide. Suicide risk is known to be especially raised soon after discharge.

Results were summarized from 62,922 Danish people who had been discharged from inpatient psychiatric services and 1,573,050 who had never been a psychiatric inpatient, examining these adverse outcomes over ten years post-discharge: mortality, suicide, accidental death, homicide victimization, homicide perpetration, non-fatal self-harm, violent criminality, and hospitalization following violence.

The risk of at least one of these adverse outcomes was highest in people using psychoactive drugs.

Although no detailed clinical information was available regarding what psychiatric treatments were given, it can be assumed that psychiatric (psychoactive) drugs were a major part of most treatments, since worldwide statistics show that a rapidly increasing percentage of every age group, from children to the elderly, rely heavily and routinely on psychiatric drugs in their daily lives. Worldwide sales of antidepressants, for example, were more than $14 billion in 2017, and expected to surpass $15 billion by 2023.

These statistics give one more result in a long line of significant research that concludes:

  • psychiatry cannot cure any so-called mental illness
  • psychiatric treatments cause violence and suicide
  • psychiatric treatments actually harm rather than help vulnerable people
  • psychiatry is junk science
  • psychiatric drugs can only chemically mask problems and symptoms; they cannot and never will be able to solve problems

People in desperate circumstances must be provided proper and effective medical care. Medical, not psychiatric, attention, good nutrition, a healthy, safe environment and activity that promotes confidence will do far more than the brutality of psychiatry’s treatments.

While life is full of problems, and sometimes those problems can be overwhelming, it is important for you to know that psychiatry, its diagnoses and its drugs are the wrong way to go.

You’re Not Paranoid, It’s Really Happening

Abilify Mycite® (aripiprazole tablets with sensor, from Otsuka Pharmaceutical) is a prescription drug of an aripiprazole tablet (an atypical antipsychotic) with a metallic Ingestible Event Marker (IEM) sensor inside it, used in adults for diagnoses of schizophrenia, bipolar I disorder, and major depressive disorder. A month’s supply of it costs around $1,650. The actual mechanism of action of aripiprazole is unknown, although it messes with the levels of dopamine and serotonin in the brain, which is playing Russian Roulette with your mind.

The sensor is intended to track, with a smartphone app, if the drug has been taken. The ability of this drug to improve patient compliance or modify dosage has not been established. The only thing the FDA approved was functions related to tracking drug ingestion. The use of this drug to track drug ingestion in real-time or during an emergency is not recommended because detection may be delayed or not occur.

The drug sends information to a patch worn on the patient’s arm, which is then logged on a mobile app, which then sends the data to their doctor. Some experts warn that the idea of swallowing a tracking chip may be too much for paranoid patients to handle.

Said one expert, “I am concerned about the formation of new pharmaceutical persons who are digitally enhanced to be compliant with the profit motives of corporations and the directives of health providers and drug companies. … The fact that the drug is Abilify, which is prescribed to people who experience serious mental distress, should raise many ethical red flags. These concerns are especially relevant because the patent for the original Abilify drug expired in 2016… My concern is that … the company will be motivated to profit from the technology as much as possible, regardless of whether the drug actually improves health.”

The idea for this gross invasion of privacy comes about because refusing to take prescribed drugs is a particular psychiatric concern, and is even enshrined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) as “Nonadherence to medical treatment.”

Abilify MyCite is still not widely used in the US, possibly because of skepticism from patients, prescribing doctors and insurance providers, although Otsuka has collaborated with Magellan Health to roll the drug out to the US, and UnitedHealthcare has developed complex rules for insurance authorization.

This drug has potentially severe side effects including stroke; akathisia; neuroleptic malignant syndrome; tardive dyskinesia; unusual urges such as compulsive gambling, sex, eating, or shopping; seizures; suicidal thoughts or behaviors. Side effects may be considerably more severe with known CYP2D6 poor metabolizers (a Cytochrome P450 enzyme.)

This drug also has a Boxed Warning about an increased risk of suicidal thinking and behavior in children, adolescents and young adults.

Recognize that the real problem is that psychiatrists fraudulently diagnose life’s problems as an “illness”, and stigmatize unwanted behavior as “diseases.” Psychiatry’s stigmatizing labels, programs and treatments are harmful junk science; their diagnoses of “mental disorders” are a hoax — unscientific, fraudulent and harmful.

If you are taking this drug, do not stop suddenly. You could suffer serious withdrawal symptoms. You should seek the advice and help of a competent medical doctor or practitioner before trying to come off any psychiatric drug.

Chanting the Chantix Mantra

Recently there has been a gross increase in the TV ad campaign for Chantix, promoting this deadly drug for smoking cessation.

We’ve written about Chantix before, but we thought a repeat was in order due to this massive ad campaign.

In 2008 the Federal Aviation Administration banned Chantix for pilots and air traffic controllers, and reissued that decision in 2013.

The U.S. Food and Drug Administration (FDA) slapped a “Black Box” warning on Chantix (varenicline tartrate, made by Pfizer) in 2009 after receiving thousands of reports linking the drug to mental health issues, including suicidal thoughts, hostility and agitation.

In 2015, the FDA expanded the warning to note that the drug had also been linked to reduced alcohol tolerance leading to seizures.

However, in 2016 the FDA removed the Black Box warning, after heavy lobbying from Pfizer claiming that additional data showed that the benefits of Chantix outweighed its adverse side effects (oh, and since its sales had significantly dropped.)

But the adverse side effects did not go away; only the Black Box warning went away. One study found that Chantix had more cases of suicidal thoughts, self-harm, and homicidal thoughts than any other drug, by a more than three-fold margin. Pfizer’s prescribing information still warns about new or worsening mental health problems such as changes in behavior or thinking, aggression, hostility, agitation, depressed mood, or suicidal thoughts or actions while taking or after stopping Chantix.

We suspect that the recent spate of TV ads is related to the removal of the Black Box warning and the prior drop in sales. Also, the price of Chantix more than doubled between 2013 and 2018. In 2013, Pfizer paid out $273 million to settle a majority of the 2,700 state and federal lawsuits that had been filed over adverse side effects. Now the company is trying to grow the market with clinical studies for smokers age 12 to 19.

What is Chantix?

Chantix is a psychiatric drug — a benzodiazepine-based anti-anxiety drug, also called a minor tranquilizer or sedative hypnotic. Daily use of therapeutic doses of benzodiazepines are associated with physical dependence, and addiction can occur after 14 days of regular use. Typical consequences of withdrawal are anxiety, depression, sweating, cramps, nausea, psychotic reactions and seizures. There is also a “rebound effect” where the individual experiences even worse symptoms than they started with as a result of chemical dependency.

The exact mechanism of action of benzodiazepines is not known, but they affect neurotransmitters in the brain and suppress the activity of nerves, under the unproven theory that excessive activity of nerves may be the cause of anxiety. Chantix was developed to specifically affect nicotinic receptors in the brain, under the theory that this would reduce nicotine craving and block the rewarding effects of smoking. Messing with neurotransmitters in the brain is playing Russian Roulette with your mind.

Benzodiazepines are metabolized by cytochrome P450 enzymes, so a genetic lack of these enzymes can cause a buildup of harmful toxins and increase the severity of adverse side effects.

Psychiatric “best practices” consider that smoking is an addiction and recommend that psychiatrists assess tobacco use at every patient visit, since tobacco addiction is covered in the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) as a “mental illness” under eight separate items, and disorders related to inhalant use have 33 entries. Smoking is not a mental illness and addiction cannot be fixed with psychiatric drugs.

The psychiatric industry considers that smoking cessation therapies are their territory, however this drug masks the real cause of problems in life and debilitates the individual, thus denying one the opportunity for real recovery and hope for the future. Treating substance abuse with drugs is a major policy blunder; contact your state and federal representatives and let them know you disapprove of this trend.

Recognize that the real problem is that psychiatrists fraudulently diagnose life’s problems as an “illness”, and stigmatize unwanted behavior like smoking as a “disease.” Psychiatry’s stigmatizing labels, programs and treatments are harmful junk science; their diagnoses of “mental disorders” are a hoax — unscientific, fraudulent and harmful. All psychiatric treatments, not just psychiatric drugs, are dangerous.

The Psychiatric Scientific Double Standard

When it comes to psychiatric scientific research, there is a double standard that favors what makes money and disavows what does not make money. When we say “double standard” we mean some rule or principle which is unfairly applied in different ways to different groups or situations, or that favors one group or situation over another. The actual principle in question here is called “evidence-based science.”

Many scientists, particularly those in the psychiatric-pharmaceutical industry, mouth that they favor “evidence-based science” when in fact they favor what can make the most money regardless of the evidence.

A recent Scientific American editorial (“The WHO Takes a Reckless Step“, April, 2019) denigrates Traditional Chinese Medicine because it is purportedly not “evidence-based.”

Yet Scientific American promotes psychiatry and psychiatric drugs, when it knows that every psychiatric drug on the market has somewhere in its fine print a statement to the effect that “we don’t know how it works,” while the FDA approves these drugs based on so-called “evidence.”

Here are some representative quotes:

  • The fine print for Rexulti (brexpiprazole, an antipsychotic) says, “the exact way REXULTI works is unknown”.
  • The fine print for Latuda (lurasidone, an antipsychotic) says, “It’s not known exactly how LATUDA works, and the precise way antipsychotics work is also unknown”.
  • The fine print for Xanax (alprazolam, a benzodiazepine anti-anxiety drug) says, “Their exact mechanism of action is unknown”.

So much for evidence-based practice! The actual evidence is, they don’t have a clue how these drugs are supposed to work — it’s all conjecture!

As we continue to examine the actual evidence, we come up against the adverse reactions, or side effects, of these drugs. This is hard evidence, not conjecture.

What is a Side Effect?

Side effects (also called “adverse reactions”) are the body’s natural response to having a chemical disrupt its normal functioning.

One could also say that there are no drug side effects, these adverse reactions are actually the drug’s real effects; some of these effects just happen to be unwanted.

The FDA takes the adverse side effect of suicide seriously by placing a Black Box Warning on certain psychiatric drugs. For example, the FDA says that “Antidepressants increase the risk of suicidal thinking and behavior (suicidality) in children and adolescents with MDD [Major Depressive Disorder] and other psychiatric disorders.”

What about those who say psychotropic drugs really did make them feel better? Psychotropic drugs may relieve the pressure that an underlying physical problem could be causing but they do not treat, correct or cure any physical disease or condition. This relief may have the person thinking he is better but the relief is not evidence that a psychiatric disorder exists. Ask an illicit drug user whether he feels better when snorting cocaine or smoking dope and he’ll believe that he is, even while the drugs are actually damaging him. Some drugs that are prescribed to treat depression can have a “damping down” effect. They suppress the physical feelings associated with “depression” but they are not alleviating the condition or targeting what is causing it.

Once the drug has worn off, the original problem remains. As a solution or cure to life’s problems, psychotropic drugs do not work.

For the first time the side effects of psychiatric drugs that have been reported to the U.S. Food and Drug Administration (FDA) by doctors, pharmacists, other health care providers and consumers have been decrypted from the FDA’s MedWatch reporting system and been made available to the public in an easy to search psychiatric drug side effects database and search engine. This database is provided as a free public service by the mental health watchdog, Citizens Commission on Human Rights International (CCHR).

Hear This — Zone Out on Zonisamide

The March 15-21, 2019 issue of the St. Louis Business Journal noted a $10.5 million Army grant to the Washington University in St. Louis Medical School to study the epilepsy drug Zonisamide to see if it could prevent hearing loss from loud noises. This seemed like such an imaginative stretch that we decided to look into it in more detail.

The justification given is that Zonisamide is conjectured to protect hearing loss when given ahead of exposure to loud noises. We wondered how this came about. We also note that other epilepsy drugs are psych-related, so we wondered if there was a psych drug connection here as well.

In a rat study, researchers proposed using a substance that blocks calcium channels to see if it could prevent hearing loss against loud noises. Zonisamide also blocks calcium channels. Gee, maybe Zonisamide can prevent hearing loss.

Zonisamide is the generic name used in the United States for a seizure drug whose common brand name is Zonegran. It was first used in Japan in the early 1970’s to treat so-called psychiatric disorders, and has been used off-label by psychiatrists in the U.S. as a mood stabilizer. The FDA approved it for seizures in 2000, although it is totally unknown as to how it works to prevent seizures. The FDA notes that taking this drug may increase the risk of depression, psychosis and suicidal thoughts or actions.

Using Zonisamide during pregnancy may present a significant risk to the fetus due to the possibility of birth defects.

Zonisamide was first studied in Japan in the 1970’s during exploratory research on drugs for psychiatric disorders. The drug alters the concentration of dopamine in the brain, but is apparently dosage dependent — that is, different dosages can increase or decrease dopamine concentrations, leading to unpredictable results.

Zonisamide is metabolized in the liver by Cytochrome P450 enzymes, so its side effects can be magnified in those persons with a genetic lack of these enzymes.

Typically we see that the psychiatric research community makes a guess about re-purposing some old drug so it can be re-used for a new patient population, guesses how it might work in the rat brain, then guesses how it might work in the human brain, each time asking for more funding to make further guesses, eventually leading to the FDA approving a new use for an old drug even though they still don’t know how it “works.”

While medicine has advanced on a scientific path to major discoveries and cures, psychiatry has never evolved scientifically and is no closer to understanding or curing mental problems, thus must continually seek to find new uses for old treatments.

While medicine has nurtured an enviable record of achievements and general popular acceptance, the public still links psychiatry to snake pits, straitjackets, and “One Flew Over the Cuckoo’s Nest.” Psychiatry continues to foster that valid impression with its development of such brutal treatments as ECT, psychosurgery, the chemical straitjacket caused by antipsychotic drugs, and its long record of treatment failures including Zonisamide as a mood stabilizer.

In over 40 years, “biological psychiatry” has yet to validate a single psychiatric condition/diagnosis as an abnormality/disease, or as anything neurological, biological, chemically imbalanced or genetic.

The drugs prescribed for psychiatric conditions, such as using Zonisamide as a mood stabilizer, only exacerbate the conditions they are supposed to treat. And when these drugs are used for other non-psychiatric conditions, they continue having the same adverse reactions, such as depression and suicide when Zonisamide is used for epilepsy. It will have the same adverse reactions if it is ever used for hearing loss. And they will still not know how it “works.”

We suggest that funding only be provided for workable medical treatments that dramatically improve and cure health and mental health problems. For more information, download and read the CCHR booklet “Psychiatric Hoax – The Subversion of Medicine – Report and recommendations on psychiatry’s destructive impact on health care.

Knock Yourself Out with Spravato (Esketamine)

A nasal spray version of the anesthetic drug ketamine was approved by the FDA on March 5, 2019 for treatment-resistant depression.

Janssen Pharmaceuticals says that the cost for a one-month course of treatment for Spravato (generic esketamine) will be between $4,720 and $6,785.

Esketamine is the S-enantiomer of ketamine, which means that it is one of the two mirror images of the chemical structure of ketamine, S (for the Latin sinister) being the left image. It enhances glutamine release in the brain. Glutamine is an amino acid used in the synthesis of proteins, among other things. In the brain, glutamine is used in the production of neurotransmitters. It is believed that glutamine plays a role in raising or lowering aggression levels.

Treatment requires that doses be taken, in conjunction with an oral antidepressant, in a doctor’s office or clinic, with patients monitored for at least two hours, and their experience entered in a registry.

Because of the risk of serious adverse outcomes and the potential for abuse and misuse of the drug, it is only available through a restricted distribution system. At least you can’t take it home with you.

The Spravato labeling contains a Boxed Warning that cautions that patients are at risk for sedation and difficulty with attention, judgment and thinking (dissociation), abuse and misuse, and suicidal thoughts and behaviors after administration of the drug.

Basically, it knocks you out so you don’t feel so depressed anymore. You don’t feel much of anything, actually, since you’ve just taken an anesthetic in the snout.

There were four phase 3 clinical trials; two of them failed to show any statistical improvement, but the drug was approved anyway because it was on the Fast Track and Breakthrough Therapy paths.

A 9/5/2018 update from Consumer Reports said, “All these drugs [Ketamine, Phenylbutazone, Chloramphenicol] are prohibited in beef, poultry, and pork consumed in the U.S. Yet government data obtained by Consumer Reports suggest that trace amounts of these and other banned or severely restricted drugs may appear in the U.S. meat supply more often than was previously known.”

Note that “depression” is not an actual medical illness; it is simply a symptom of some undiagnosed and untreated condition. A diagnosis of depression is a prime example of psychiatric fraud.

Any form of ketamine used to treat so-called depression is unethical and harmful, since it precludes the patient from finding out what is actually wrong and getting that treated. Psychiatrists pushing ketamine or esketamine are shameful drug pushers who are making a buck off people’s misfortune.

Go here for more information about alternatives to drugs.

Is It a Drug Allergy or a Side Effect?

We noticed that most drug advertisements now say something like “Do not take this drug if you are allergic to it or any of its ingredients.” We wondered when this caveat started.

We have repeatedly warned about the side effects of psychiatric drugs, also called adverse reactions. Side effects are the body’s natural response to having a chemical disrupt its normal functioning. One could also say that there are no drug side effects, these adverse reactions are actually the drug’s real effects; some of these effects just happen to be unwanted.

So we were curious about how warnings of drug side effects have apparently morphed into warnings about being allergic to drugs. Was this another example of the psycho-pharmaceutical industry redefining terms to downplay the adverse reactions?

Well, what is an allergy? Allergies occur when the immune system overreacts to a foreign substance by producing antibodies which identify the substance as harmful. The word itself comes from German allergie, from Greek allos “other” + Greek ergon “work” or “action”.

We often think of an allergic reaction as from something environmental, such as inhaling pollen, which causes the immune system to reject the substance.

The experts say that the difference between an allergy and a side effect is that an allergy generally results from the immune system rejecting the substance, and a non-allergic side effect is a predictable result from some particular chemical or biological property of the substance not involving the immune system.

We get the difference, but we still see the psycho-pharmaceutical industry starting to emphasize allergic reactions over side effects in their public relations campaigns, even though allergic reactions are rare compared to side effects, reported as less than 10% of the cases.

The implication seems to be that an allergic reaction is not the drug’s fault, it’s the body’s reaction, whereas a side effect is caused by the drug. We think the distinction is moot, but is being used to downplay drug side effects and transfer the attention and blame off the drugs.

One reference says this about it: “A drug allergy occurs when your immune system mistakenly identifies a drug as a harmful substance.” Aha, a deliberate attempt to cast drugs as non-harmful.

The literature shows discussions about the difference between allergy and side effect over many years, but it’s only recently that we’ve noticed the emphasis in advertisements on allergy instead of side effect.

There are also some genetic effects that confuse the issue. An adverse reaction can also be a reaction to drugs or toxins which cannot be metabolized due to a genetic lack of cytochrome P450 enzymes.

We also remind people that the real problem is that psychiatrists fraudulently diagnose life’s problems as an “illness”, and stigmatize unwanted behavior or study problems as “diseases” so that they can prescribe drugs. Psychiatry’s stigmatizing labels, programs and treatments are harmful junk science; their diagnoses of “mental disorders” are a hoax – unscientific, fraudulent and harmful. All psychiatric treatments, not just psychiatric drugs, are dangerous.

We do suggest that people review the potential known side effects of any prescribed drugs; this is one of the cardinal precepts of Full Informed Consent.